OviVance™ helps to optimise your reproductive health and ovary function before and during pregnancy. It also assists you in combatting insulin resistance related to common reproductive disorders, such as Polycystic Ovary Syndrome (or PCOS).
OviVance™ provides nutritional support for:
OviVance™ contains a unique blend of vitamins and minerals that help to optimise reproductive and foetal health. These ingredients have also been proven by independent scientific studies to assist in combatting insulin resistance related to common reproductive disorders, such as PCOS, gestational diabetes and the Metabolic Syndrome.
These ingredients are:
Inositol, a naturally occurring nutrient which exist in the body in two forms: myo (MI) and D-chiro-inositol (DCI). Both act in fertility, reproduction and metabolic health. Problems in the balance between these two forms of inositol results in reduced insulin sensitivity and poor ovary function. Clinical studies have shown that inositol, especially at the ratio provided by OviVance, improves regulation of insulin and insulin sensitivity, ovulation and follicular maturation, egg quality and quantity and restores menstrual cycle regularity.
OviVance™ contains L-5-methyltetrahydrofolate (5-MTHF), the natural form of folate, offering benefits such as better absorption and increased safety. Folate is essential to reproductive and foetal development, and supplementation improves menstrual function and regularity of ovulation, enhances reproductive outcomes and response to fertility treatment, and helps prevent neural tube defects, preeclampsia, miscarriage and congenital abnormalities. Regarding MetS and PCOS, folate aids in avoiding hyperhomocysteinemia, a condition responsible for cardiovascular damage and cancer.
Choline is a vital nutrient in liver, neurological, musculoskeletal and cellular membrane function. During reproduction and pregnancy, choline is essential due to increased cell-division and membrane synthesis, reduces placental inflammation, improves placental vascular development and angiogenesis, and leads to better neurodevelopment and further reduced chance of neural tube defects.
Vitamin A is a nutrient essential to normal growth, especially during foetal, neonatal and childhood development of the organs and immune system.
Vitamin B6, a coenzyme in over one hundred enzymatic reactions is known to reduce the symptoms of morning sickness, nausea, vomiting and postpartum depression. The vitamin is also involved in reducing homocysteine, benefitting PCOS patients.
Vitamin B12 is essential to optimal infant neurological development and prevention of neural tube defects, pre-term delivery and preeclampsia amongst others. The vitamin is also involved in reducing homocysteine levels alongside folate, vitamin B6 and choline.
Vitamin C is required for tissue repair, synthesis of neurotransmitters and optimal immune system function. The vitamin important to general health as well as the health of the mother and foetus during pregnancy.
Vitamin D positively affects the ability to conceive through improved egg maturation, fertilisation rates and menstrual regularity, and reduces risk for preterm birth and preeclampsia. The vitamin is also well known to assist in MetS and PCOS through reduction in insulin resistance, dyslipidaemia and obesity.
Iodine is required for synthesis of thyroid hormones, and low intake reduces fertility rates, impairs neurodevelopment, and leads to spontaneous miscarriage, congenital abnormalities and other issues in pregnancy.
Iron plays a key role in oxygen transport and energy production, growth and development. Requirements increased during pregnancy due to transfer of iron to the foetus and higher energy requirements.
Magnesium improves pregnancy rates and reduces the occurrence of preterm labour, preeclampsia and growth restriction. It also assists metabolic aspects of female health, especially in terms of MetS, PCOS and reducing the risk of gestational diabetes.
Selenium occupies major roles in immunity and redox processes. Supplementation may lessen the risk of neural tube defects and preeclampsia, while improving cognitive development. It also has well established roles in MetS and PCOS, insulin sensitization, inverse relationship with androgenic hormone levels
Zinc is important to optimal health during pregnancy, as well as addressing PCOS and MetS, especially through reducing inflammation and oxidative stress, improving insulin sensitivity, blood sugar regulation and dyslipidaemia.
One tablet contains
Inositol (myo:D-chiro inositol 40:1)
Folate (as L-5-methylhydrofolate calcium)
Choline (as choline bitartrate)
Vitamin A (beta-carotene)
Vitamin B6 (pyridoxine HCL)
Vitamin B12 (cyanocobalamin)
Vitamin C (ascorbic acid)
83 mcg RE
Iodine (as potassium iodide)
Iron (as ferrous sulphate)
Magnesium (as magnesium oxide)
Zinc (as zinc oxide)
OviVance™ can be used by anyone who is struggling to become pregnant, wants to boost their fertility, is experiencing problems with their hormonal balance or who wants to enhance the health of themselves and their baby during pregnancy. OviVance is also ideal for women suffering from PCOS or any off its symptoms, MetS, gestational diabetes or metabolic changes associated with menopause, especially if taken long term.
Take 2 tablets per day with meals. You can break or chew the tablets if you need.
You should not take OviVance™ if you are hypersensitive or allergic to any of the active or inactive ingredients of OviVance™. Using any supplements or medications while pregnant should be according to the advice of your doctor.
The ingredients contained in OviVance™ generally have low side-effect profiles even when used for extended periods. Side-effects are unlikely to be experienced at the dosages provided by OviVance™. For large doses of the individual ingredients, side-effects are mostly of a gastrointestinal nature, including abdominal discomfort or nausea. To reduce the chance of side effects, it is recommended that OviVance™ is taken with meals.
Yes, OviVance™ may be taken with most prescription drugs, including oral contraceptives and diabetic drugs such as metformin. Caution, however, must be taken with anti-diabetic medication, as the blood sugar-lowering effect of OviVance™ may enhance their action and leave you with symptoms of low blood sugar. Caution must also be taken when used with blood thinners such warfarin. It is always important to inform your doctor of what supplements you are taking, especially if you are already being treated for another condition.
Inositol is a naturally occurring vitamin B-like nutrient. Of nine stereoisomers, myo-inositol (MI) and D-chiro-inositol (DCI) are the most abundant in tissues.
MI and DCI act in fertility related hormone signalling, reproduction and metabolic health, including insulin, gonadotropin, thyroid, and anti-Müllerian hormone signalling pathways. Each isomer has varying roles as second messengers and exhibit tissue specific ratios. In polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS), dysregulation of inositol metabolism and homeostasis has been associated with a number of health outcomes, including reduced insulin sensitivity, dyslipidaemia and aberrant function of the ovaries.
In clinical settings, supplementation of inositol has been demonstrated to offer a number of benefits. These include improvement in the optimal regulation of insulin, insulin sensitivity, glycaemic and lipid levels, blood pressure control and a reduction in the prevalence and severity of gestational diabetes. Reproductive health is also positively affected, which may in part be due to improved endocrine function and reduced hyperandrogenism through increased frequency of ovulation and follicular maturation, improved oocyte quality and quantity and restoration of spontaneous ovulation and menstrual cycle regularity.
In many of these outcomes, combined treatment with MI and DCI at the physiologically relevant ratio of 40:1 has been shown to lead to more rapid improvement, resulting in the international consensus that supplementation at this ratio is optimal in treatment of a range of metabolic and reproductive abnormalities.
Folate, also known as Vitamin B9, is involved in numerous aspects of cellular function and general health. Folates cannot be synthesized by the body, and as such must be obtained from the diet. Due to the wide ranging roles of folate in metabolism, deficiency can have substantial effects on health, especially relating to foetal health during early pregnancy.
Adequate levels of folate are essential to reproductive and foetal development. Positive reproductive effects involve improved menstrual function and regularity of ovulation, partially attributed to better luteal phase progesterone measurements. Indeed, folate supplementation has been associated with enhanced reproductive outcomes and response to fertility treatment. In pregnancy, folate sufficiency is well known to prevent the development of neural tube defects in the foetus, but has also been demonstrated to be negatively associated with preeclampsia, miscarriage and congenital abnormalities such as heart defects and oral facial clefts. Furthermore, folate is essential for angiogenesis and vasculogenesis leading to adequate foeto-placental circulation, and may be involved in neurodevelopment of children.
Folate may also benefit women suffering from MetS and PCOS through its role in prevention of hyperhomocysteinemia, a condition responsible for cardiovascular damage and cancer, through its role in regulating homocysteine.
OviVance™ contains L-5-methyltetrahydrofolate (5-MTHF), the natural form of folate, as opposed to folic acid, a synthetic form that is most often found in fortified foods and supplements. Despite the widespread success of folic acid supplementation in improving health, it is believed that the natural form offers a number of benefits, such as better bioavailability through more rapid absorption.
Choline is a vital nutrient in optimal liver, neurological, musculoskeletal and cellular membrane function. The majority is obtained from animal derived foods. Vegetarians and vegans are therefore especially susceptible to choline deficiency, while the majority of pregnant and lactating women, and a large proportion of the general population, exhibit some level of choline insufficiency.
Choline deficiency can lead to a number of pathologies, including fatty liver disease, muscle damage, decreased cognitive function, cancer and homocysteinaemia. During reproduction and pregnancy, choline is essential to increased cell-division and membrane synthesis. Supplementation reduces placental inflammation, improves placental vascular development and angiogenesis, and leads to better neurodevelopment and further reduced chance of neural tube defects.
Vitamin A is a nutrient essential to normal growth, especially during foetal, neonatal and childhood development. The vitamin is well-known to be crucial for ocular integrity and development, but also has roles in development of the foetal organs and skeleton, immune system, teeth, hair, skin and mucous membranes as well as the functional capacity of reproductive organs.
As a coenzyme in over one hundred enzymatic reactions, vitamin B6 is an important nutrient in human health. The vitamin is available in many food sources of both plant and animal origin, and supplementation in the general population is believed to lead to a number of positive outcomes.
In pregnancy, the major role of Vitamin B6 supplementation has been to reduce the symptoms of morning sickness, nausea, vomiting and postpartum depression. Vitamin B6 is also involved in reducing homocysteine levels along with folate, and thus may benefit PCOS patients.
Vitamin B12 fulfils dominant roles in the synthesis and methylation of DNA and energy metabolism. It can only be obtained from animal derived foods, and supplementation is therefore especially important in vegetarians and vegans.
In relation to pregnancy and reproductive health, vitamin B12 deficiency is associated with increased risk of adverse neonatal and maternal outcomes, including pre-term delivery, low birth weight and preeclampsia. Vitamin B12 is also essential to optimal infant neurological development and prevention of neural tube defects, and increased intake is often required due to enhanced supply to the child in both pregnancy and lactation.
With regards to PCOS and MetS, vitamin B12 is involved reducing homocysteine levels, and as such may aid in preventing hyperhomocysteinaemia in women suffering from the condition. Vitamin B12 supplementation is also essential alongside that of folate, as insufficiency in conjunction with high folate levels increases risk of gestational diabetes and maternal obesity.
Vitamin C is a nutrient required for tissue repair, synthesis of neurotransmitters, optimal immune system function and redox homeostasis. Deficiency can lead to problems with collagen synthesis, amino acid metabolism and many other essential functions. The vitamin is therefore important to general health as well as the health of the mother and foetus during pregnancy.
The vitamin D’s are a group of fat-soluble steroid vitamins. Vitamin D has wide ranging effects on general health, from participating in immune function to cardiovascular and skeletal viability.
In terms of reproductive health, Vitamin D positively affects the ability to conceive through improved oocyte maturation, as well as reduces the risk for preterm birth and preeclampsia. Additionally, the vitamin is linked to placental function and skeletal and lung development in utero.
MetS and PCOS related outcomes are also affected by vitamin D status and supplementation. These include improved metabolic parameters, as well as a reduction in insulin resistance, dyslipidaemia and obesity. Higher vitamin D availability has similarly been shown to improve fertility and fertilisation rates as well as menstrual regularity among obese women with or without PCOS.
Iodine is primarily required for synthesis of thyroid hormones, especially in pregnant women where iodine requirements are increased. Iodine is essential to the health of both mother and foetus, and low intake has been implicated in reduced fertility rates, sub-optimal neurodevelopment, spontaneous miscarriage, congenital abnormalities and decreased mental acuity later in life.
Iron is a trace mineral which plays a key role in oxygen transport and energy production, as well as growth and development. Requirements are increased during pregnancy due to transfer of iron to the foetus and increased energy requirements. Supplementation has been shown to prevent iron deficiency anaemia and reduce the risk of low birthweight.
Magnesium is a trace element involved in more than 300 enzymatic reactions. Suboptimal magnesium levels or deficiency is associated with a number of disorders and requirement for the mineral increases during gestation.
Magnesium sufficiency has been linked to improved pregnancy rates and a reduction in the occurrence of preterm labour, preeclampsia, small for gestational age foetuses and growth restriction. The mineral is also associated with improving metabolic aspects of female health, especially in terms of MetS associated with PCOS and reduction in the chance of gestational diabetes.
Selenium, another trace element, plays a major role in facilitating immunity and redox processes.
In pregnancy, deficiency can lead to various adverse outcomes, including increased risk of neural tube defects and impaired cognitive development. Supplementation has also been observed to reduce the risk of preeclampsia. Additionally, selenium plays a role in MetS and PCOS, exhibiting insulin sensitization properties, an inverse relationship with androgenic hormone levels, and an ability to attenuate dyslipidaemia.
Zinc is an essential mineral required for normal health and acts as a cofactor in hundreds of enzymatic reactions.
Zinc deficiency in pregnancy is associated with various adverse outcomes, including spontaneous miscarriage, congenital malformations, intrauterine growth retardation, labour abnormalities and preterm delivery. Metabolic effects of zinc have also been observed to benefit PCOS and MetS through reducing inflammation and oxidative stress, improving insulin sensitivity and glycaemic parameters, and attenuating dyslipidaemia. Zinc supplementation in women with PCOS has demonstrated a reduction in the risk of gestational diabetes, hirsutism and androgenic alopecia.
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