NeuroVance Focus

NeuroVance Focus can assist to:

• Optimise concentration and focus
• Improve mood control and calmness
• Immune System Support
• Combat stress and anxiety
• Provides stamina for schoolwork and extramural activities

NeuroVance Focus contains a unique blend of plant-derived phytochemicals, vitamins and minerals known to help optimise mood, assist with concentration and promote healthy brain function and cognition. Its multi-modal pharmaceutical action enhances separate but interconnected components of brain function, thereby giving your brain a physiological advantage during demanding and stressful periods. The ingredients contained in NeuroVance Focus are roseroot extract, inositol, magnesium, zinc, vitamin D3 and vitamin C.

Roseroot (Rhodiola rosea) is a plant that grows at high altitudes in the arctic regions of Europe and Asia. Extracts of the roots have been used in Scandinavian and European countries as part of traditional Western medicine to combat fatigue, reduce the effects of stress and to aid with recovery during illness.

Inositol is a natural carbohydrate present in a variety of foods. The highest concentrations are naturally found in fruits, especially cantaloupe and oranges, and in some beans, grains, and nuts. Various scientific studies on inositol supplementation have demonstrated therapeutic efficacy regarding emotional wellbeing and stress reduction.

Magnesium is a biologically essential trace element which plays a dominant role in the regulatory activity of over 300 enzymatic processes involved in optimal brain function, including nerve conduction and the production of neurotransmitters.

Zinc is a crucial micro-nutrient and co-factor in many biological processes including DNA, RNA, and protein synthesis. Zinc also plays a key role in various mental functions such as behaviour and learning.

Vitamin D3 modulates several enzyme systems in the brain and the cerebrospinal fluid involved in neurotransmitter synthesis and nerve growth. Moreover, recent studies have shown Vitamin D to possess a neuroprotective effect as well as reduce neuroinflammation, thereby improving cognitive function.

Vitamin C has a number of neurological functions including but not limited to; the regulation of neurotransmitter biosynthesis such as dopamine, adrenaline, and noradrenaline. Individuals who have vitamin C deficiency often report feeling both depressed and fatigued and some cases anxious.

Each 10ml contains:

Free from: Sucrose, Lactose, Gluten and Tartrazine.
Inactive ingredients: Purified water, citric acid, strawberry flavour, non-nutritive sweetener (sodium cyclamate, acesulfame k), strawberry colourant, xanthan gum, glycerine, sorbitol (70%), hydrochloric acid (34%) and preservatives (potassium sorbate, sodium benzoate). 

Anyone suffering from mental exhaustion, stress or emotional hardship can benefit from NeuroVance Focus. It is ideal during times of extreme work pressure, exams, conflict, bereavement, loss or whenever you need that extra push to help you focus on your day to day activities. NeuroVance Focus can be used as a daily supplement to help you reach peak mental performance and providing extra stamina during schoolwork and extramural activities.

Children between 7 and 8 years: Take one sachet daily with meals (During breakfast or lunch time).

Children between 8 and 12 years: Take one sachet twice a day with meals (During breakfast and lunchtime).

Adults and children over 12 years: Take two sachets daily with meals (During breakfast or lunchtime).

Children under 7 years:  Use not recommended in children younger than 7 years.

NeuroVance Focus should not be used if you:

• Are hypersensitive or allergic to any of the ingredients contained within NeuroVance Focus
• Are pregnant or breastfeeding.
• Are using an antidepressant that belongs to the class of monoamine oxidase inhibitors [MAOIs] such as tranylcypromine and moclobemide.
• Are below seven years of age.

The individual ingredients contained within NeuroVance Focus are generally considered to have a low side effect profile and no side effects should be experienced at the dosage provided. Mild gastro-intestinal irritation may occur as well as insomnia if taken late during the day. NeuroVance Focus is non-stimulatory and non-sedative.

Yes, NeuroVance Focus may be used in combination with all the above products, except antidepressant medication that belongs to the class of monoamine oxidase inhibitors (MAOIs) such as tranylcypromine and moclobemide. Consult your doctor if you are unsure about combining NeuroVance Focus with any of your medication.

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• South Africa at any pharmacy.  No prescription is required.
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NeuroVance Focus contains a unique blend of plant-derived phytochemicals, vitamins and minerals that aid with the regulation of mood and concentration under stressful conditions. These are listed below:

Roseroot extract

Roseroot (Rhodiola rosea), also known as “arctic root” or “golden root”, is a perennial plant that grows at high altitudes in the arctic regions of Europe and Asia. Extracts of the rhizomes and roots have been used in traditional Western medicine in Scandinavian and European countries to combat fatigue, reduce the effects of stress and to aid convalescence during illness. Roseroot extract has a long history of documented use and appears in the Materia Medica of several European countries. During the early 19th century in France it was recommended as a “brain tonic” in literature. In the Swedish Drug and Therapy Handbook (Lakemedelsboken 1997/98), roseroot extract is classified as one of the most commonly used herbal neuro-adaptogens in Sweden. Preparations containing roseroot extract are typically used to increase concentration and enhance mental performance during times of emotional and physical hardship.

Roseroot extract contains various chemical classes including flavonoids, phenolic acids, phenylethanol derivatives (salidroside and tyrosol) and phenylpropanoid glycosides (rosiridin, rosin, rosavin and rosarin). In vitro studies have demonstrated that rosiridin potently inhibits the action of both monoamine oxidase A and B, two key enzymes responsible for the degradation of monoamine neurotransmitters such as serotonin, noradrenaline, and dopamine. It has therefore been proposed that a possible mechanism of action explaining roseroot extract’s effect could potentially be linked to its ability to influence levels of certain mood-regulating neurotransmitters in the brain (Dierman et al. 2009).

Several studies have examined the influence of roseroot extract in relation to symptoms of mental and physical fatigue under stressful conditions. A randomised, double blind, placebo-controlled trial evaluated the effects in subjects suffering from stress-related fatigue by measuring salivary cortisol levels in addition to performing various psychometric stress and cognitive assessments. Cortisol is a known stress hormone and is involved in the regulatory mechanism of the stress response. Subjecting animals and humans to chronic stress produces characteristic changes in the hypothalamic-pituitary-adrenal axis (HPA), including an increase in the level of cortisol and a reduction in the sensitivity of the HPA to feedback inhibition. The hyper-secretion of cortisol may under certain conditions be considered a potential marker to indicate increased stress levels. In this study, the post treatment cortisol response to awakening was significantly reduced in subjects who had received roseroot extract for a period of 28 days, as compared to the placebo-control group (n=60). Several psychometric tests conducted on the same subjects demonstrated a substantial reduction in fatigue-related symptoms and an improvement of various cognitive indicators associated with psychological stress (Olsson et al. 2008). Three double-blind, placebo-controlled studies have also evaluated the effects of roseroot extract in relation to mental performance on subjects that were exposed to increased levels of stress (N total =250). Endpoints included mental work capacity, as measured by various cognitive assessment models. In all trials, mental performance against a background of fatigue caused by stress was significantly improved when compared to a placebo control group (Spasov et al. 2000, Darbinyan v2002, Shevtsov et al. 2003). Two double-blind, placebo-controlled studies evaluated the effects of roseroot extract on subjects in relation to measurable mood disturbances as determined by DSM – IV criteria, namely generalised anxiety disorder (GAD) and mild to moderate depression (N total = 99). In both studies, statistically significant differences were reported in various depression and anxiety scale scores in subjects taking roseroot extract as compared to the placebo control group (Bystritsky et al. 2008, Darbinyan et al. 2000).

Inositol

Inositol (C₆H₁₂O₆) is a natural isomer of glucose and is present in a variety of foods. The highest concentrations are found naturally in fruits, especially cantaloupe and oranges, and as a component of phosphates or phospholipids in beans, grains, and nuts. Inositol occurs in 9 different stereo-isomeric forms, with myo-inositol being the most dominant and widely distributed in nature. Inositol is a key metabolic precursor in the phosphoinositide (PI) cycle, a second messenger linked to norepinephrine, serotonin and other receptors thought to be involved in affective and anxiety disorders. Dietary inositol is incorporated into neuronal cell membranes as inositol phospholipids where it serves as a key metabolic precursor to several subtypes of adrenergic, cholinergic, serotonergic, and metabotropic neuro-receptors in the brain. Behavioural and biochemical studies indicate that inositol lipids have the potential to alter receptor sensitivity, direct membrane trafficking events and modulate signalling proteins (Harvey et al. 2002). Various scientific studies on inositol supplementation have also demonstrated therapeutic efficacy regarding emotional wellbeing and stress reduction. These include three separate double-blind, placebo-controlled studies, published in the American Journal of Psychiatry, illustrating an improvement superior to placebo of symptoms associated with panic disorder, depression, and obsessive-compulsive disorder (Benjamin et al. 1995, Levine et al. 1995, Fux et al. 1996). Another double-blind, crossover study found high dose inositol supplementation equal to that of fluvoxamine in reducing symptoms of panic disorder (Palatnik et al. 2001).

Magnesium

Magnesium is a biologically essential trace element which plays an essential role in the regulatory activity of over 300 enzymes involved in nerve conduction and the production of neurotransmitters. Magnesium helps to calm the nervous system down due to the mineral’s ability to block brain N- NMDA receptors (methyl D-aspartate), thereby inhibiting excitatory neurotransmission and mental overload. Inadequate magnesium levels have been linked to insomnia, anxiety, increased pain perception, and several neuropsychiatric problems. Conversely, studies on magnesium supplementation have shown significant improvement overall emotional well-being, sleep patterns, anxiety levels and mood.

Zinc

Zinc is one of the most abundant trace minerals in the brain and supports several physiological, biochemical, and neurological functions. The bioavailability of zinc can influence central nervous system (CNS) function through a variety of mechanisms, and diets deficient in zinc have been known to result in behavioural disturbances and diminished brain function. (A meta-analysis of 17 studies with 1643 depressed and 804 control participants demonstrated that peripheral serum zinc concentrations were approximately -1.85 µmol/L lower in depressed participants). While the exact role of zinc in the pathophysiology of depression remains unclear, the inverse relationship between zinc levels and depression has been established in several studies that evaluated zinc bioavailability in depressed patients. Conversely, a meta-analysis of randomised, controlled studies that included over 450 depressed patients demonstrated that zinc supplementation, when taken in conjunction with an antidepressant, showed significant reductions in depressive mood scores and outperformed scores from patients on antidepressants alone. Low plasma zinc levels have been associated with impairments in information processing and increased impulsivity in humans.

Vitamin D3

Vitamin D receptors are abundant throughout the central nervous system (CNS), especially in the hippocampus, a region of the brain that plays an essential role in the consolidation of information and the regulation of both short- and long-term memory. Research has also shown that vitamin D modulates several enzyme systems in the brain and the cerebrospinal fluid involved in neurotransmitter synthesis and nerve growth. Moreover, recent studies have shown Vitamin D to possess a neuroprotective effect as well as reduce neuroinflammation, thereby improving cognitive function.

Vitamin C

One of the best-established neurological functions of vitamin C is in the regulation of neurotransmitter biosynthesis such as dopamine, adrenaline, and noradrenaline. Individuals who have vitamin C deficiency often report feeling both depressed and fatigued. Conversely, studies of hospitalised patients — who often have lower than normal vitamin C levels — have found a significant improvement in mood after receiving vitamin C supplementation. But vitamin C supplements might help improve mood even for people who are not known to have low vitamin C levels, as demonstrated by several studies. One study of high school students indicated that vitamin C supplementation lowered anxiety levels, while other studies have shown overall mood-elevating effects, including the reduction of anger.