NeuroVance optimises brain function and combats stress. NeuroVance is the only 2-in-1 product able to combat stress and mental exhaustion by supporting healthy brain function rather than by acting as a sedative or stimulant. Its unique blend of plant-based, natural, ingredients works fast and is safe for daily use.
NeuroVance contains a unique blend of plant-derived (phytochemical) ingredients that have the potential to support healthy brain function via multiple pathways. Its multi-modal pharmaceutical action enhances separate but interconnected components of brain function, thereby giving your brain a physiological advantage during demanding and stressful periods. The ingredients contained in NeuroVance are roseroot extract, inositol, magnesium and zinc.
One tablet contains:
|Roseroot extract (Rhodiola rosea)||100mg|
Free from: Sucrose, Lactose, Gluten and Tartrazine.
Anyone suffering from mental exhaustion, stress or emotional hardship can benefit from NeuroVance. It is ideal during times of extreme work pressure, exams, conflict, bereavement or loss. NeuroVance can also be used as a daily supplement to help you reach peak mental performance.
For acute stressful conditions: Take 2 tablets twice a day with meals
For chronic stressful conditions and to assist with concentration: Take 1 – 2 tablets twice a day with meals
NeuroVance should not be used if you:
The individual ingredients contained within NeuroVance are generally considered to have a low side effect profile. Mild gastro-intestinal irritation may occur. NeuroVance is non-stimulatory and non-sedative.
NeuroVance contains a unique blend of phytochemical (plant-derived) compounds that aid with the regulation of mood and concentration under stressful conditions. These are roseroot extract and inositol.
Roseroot (Rhodiola rosea), also known as “arctic root” or “golden root”, is a perennial plant that grows at high altitudes in the arctic regions of Europe and Asia. Extracts of the rhizomes and roots have been used in traditional Western medicine in Scandinavian and European countries to combat fatigue, reduce the effects of stress and to aid convalescence during illness. Roseroot extract has a long history of documented use and appears in the Materia Medica of several European countries. During the early 19th century in France it was recommended as a “brain tonic” in literature. In the Swedish Drug and Therapy Handbook (Lakemedelsboken 1997/98), roseroot extract is classified as one of the most commonly-used herbal neuro-adaptogens in Sweden. Preparations containing roseroot extract are typically used to increase concentration and enhance mental performance during times of emotional and physical hardship.
Roseroot extract contains various chemical classes including flavonoids, phenolic acids, phenylethanol derivatives (salidroside and tyrosol) and phenylpropanoid glycosides (rosiridin, rosin, rosavin and rosarin). In vitro studies have demonstrated that rosiridin potently inhibits the action of both monoamine oxidase A and B, two key enzymes responsible for the degradation of monoamine neurotransmitters such as serotonin, noradrenaline and dopamine. It has therefore been proposed that a possible mechanism of action explaining roseroot extract’s effect could potentially be linked to its ability to influence levels of certain mood-regulating neurotransmitters in the brain (Dierman et al. 2009).
Several studies have examined the influence of roseroot extract in relation to symptoms of mental and physical fatigue under stressful conditions. A randomised, double blind, placebo-controlled trial evaluated the effects in subjects suffering from stress-related fatigue by measuring salivary cortisol levels in addition to performing various psychometric stress and cognitive assessments. Cortisol is a known stress hormone and is involved in the regulatory mechanism of the stress response. Subjecting animals and humans to chronic stress produces characteristic changes in the hypothalamic-pituitary-adrenal axis (HPA), including an increase in the level of cortisol and a reduction in the sensitivity of the HPA to feedback inhibition. The hyper-secretion of cortisol may under certain conditions be considered a potential marker to indicate increased stress levels. In this study, the post treatment cortisol response to awakening was significantly reduced in subjects who had received roseroot extract for a period of 28 days, as compared to the placebo-control group (n=60). Several psychometric tests conducted on the same subjects demonstrated a substantial reduction in fatigue-related symptoms and an improvement of various cognitive indicators associated with psychological stress (Olsson et al. 2008). Three double-blind, placebo-controlled studies have also evaluated the effects of roseroot extract in relation to mental performance on subjects that were exposed to increased levels of stress (N total =250). Endpoints included mental work capacity, as measured by various cognitive assessment models. In all trials, mental performance against a background of fatigue caused by stress was significantly improved when compared to a placebo control group (Spasov et al. 2000, Darbinyan v2002, Shevtsov et al. 2003). Two double-blind, placebo-controlled studies evaluated the effects of roseroot extract on subjects in relation to measurable mood disturbances as determined by DSM – IV criteria, namely generalised anxiety disorder (GAD) and mild to moderate depression (N total = 99). In both studies, statistically significant differences were reported in various depression and anxiety scale scores in subjects taking roseroot extract as compared to the placebo control group (Bystritsky et al. 2008, Darbinyan et al. 2000).
Inositol (C6H12O6) is a natural isomer of glucose and is present in a variety of foods. The highest concentrations are found naturally in fruits, especially cantaloupe and oranges, and as a component of phosphates or phospholipids in beans, grains and nuts. Inositol occurs in 9 different stereo-isomeric forms, with myo-inositol being the most dominant and widely distributed in nature. Inositol is a key metabolic precursor in the phosphoinositide (PI) cycle, a second messenger linked to norepinephrine, serotonin and other receptors thought to be involved in affective and anxiety disorders. Dietary inositol is incorporated into neuronal cell membranes as inositol phospholipids where it serves as a key metabolic precursor to several subtypes of adrenergic, cholinergic, serotonergic and metabotropic neuro-receptors in the brain. Behavioural and biochemical studies indicate that inositol lipids have the potential to alter receptor sensitivity, direct membrane trafficking events and modulate signalling proteins (Harvey et al. 2002). Various scientific studies on inositol supplementation have also demonstrated therapeutic efficacy regarding emotional wellbeing and stress reduction. These include three separate double-blind, placebo-controlled studies, published in the American Journal of Psychiatry, illustrating an improvement superior to placebo of symptoms associated with panic disorder, depression and obsessive-compulsive disorder (Benjamin et al. 1995, Levine et al. 1995, Fux et al. 1996). Another double-blind, crossover study found high dose inositol supplementation equal to that of fluvoxamine in reducing symptoms of panic disorder (Palatnik et al. 2001).
Magnesium is a biologically essential trace element which plays a dominant role in the regulatory activity of over 300 enzymes involved in optimal nerve conduction, the production of neurotransmitters and the synthesis of ATP, DNA, and RNA.
Zinc is a biologically essential trace element and co-factor in many biological processes including DNA, RNA and protein synthesis. Zinc also plays a key role in various mental functions such as behaviour and learning.