What does RyChol do?
Independent research has shown that the individual plant-derived ingredients contained within this unique blend may help to stabilise blood cholesterol and triglyceride levels by targeting multiple biological pathways*.
*High Cholesterol levels
What does RyChol contain?
RyChol contains a blend of plant-derived (phytochemical) ingredients that have each been recognised to help reduce blood cholesterol levels in a unique and individual manner.
Plant- or phytosterols are naturally-occurring plant fats that are structurally similar to cholesterol. They are present in all vegetable food sources, especially oils and nuts, as well as in minute amounts in food products from fish or animal origin. Due to their structural similarity to cholesterol, phytosterols compete with cholesterol absorption in the intestines.
Apples contain several biologically active polyphenols that include the flavonoids and phenolic acids. Observational studies have indicated that the regular intake of apples and apple polyphenols can modulate certain pathological processes involved in the development of various degenerative disease states. Apple polyphenols have been shown to help block the digestion of saturated fat in the digestive tract, thereby helping to reduce the absorption of fat.
Coenzyme Q10 is a fat-soluble
Barberry root extract contains a botanical chemical called berberine that is naturally found in the roots, stems and bark of various plants such as Chinese goldthread, barberry and goldenseal. It has historically been used in both Ayurvedic and Chinese traditional medicine for over a thousand years. Berberine has been demonstrated to lower cholesterol levels by increasing cholesterol clearance through the liver. This is achieved through a process called ‘up-regulation’ whereby increased numbers of liver LDL receptors are produced, thereby leading to the accelerated clearance of LDL cholesterol from the system.
Who may benefit from taking RyChol
Anyone with a high blood cholesterol level or an increased risk for
What is the usual dosage?
To help stabilise high blood cholesterol levels and reduce the risk for
Take 2 tablets twice per day with meals.
Who should not use RyChol?
RyChol should not be used under the following conditions:
If you are hypersensitive or allergic to any of the ingredients contained within RyChol.
- If you are pregnant or breastfeeding.
- If you suffer from sitosterolemia (an extremely rare autosomal disorder in which plasma concentrations of plant sterols are abnormally elevated).
Are there any side effects?
The individual ingredients contained within RyChol are generally considered to have a low side effect profile. Mild
Can RyChol be used in conjunction with the statins?
Yes, trials done on some of the individual ingredients contained within RyChol, such as phytosterols berberine and coenzyme Q10, have indicated favourable results when used in conjunction with the class of statins.
Where can RyChol be obtained?
- Shop Online
- South Africa At any pharmacy. No prescription is required.
- Namibia At any pharmacy. No prescription is required.
- International Email us at email@example.com for international purchasing information.
Pharmacological mode of action
Cholesterol homeostasis is controlled by several metabolic pathways and involves cholesterol absorption, synthesis, transport and excretion. RyChol contains a blend of phytochemical (plant-derived) compounds that have each demonstrated an ability to help regulate blood cholesterol levels via a distinctive mechanism. These are phytosterols, apple polyphenols barberry root extract and Co-enzyme Q10.
Plant- or phytosterols are naturally-occurring plant fats that are structurally similar to cholesterol. They are present in all vegetable food sources, especially oils and nuts, as well as in minute amounts in food products from fish or animal origin. Although phytosterols and cholesterol have similar chemical structures, they differ markedly in their synthesis, intestinal absorption and metabolic fate. Unlike cholesterol, phytosterols are poorly absorbed. Whilst up to 60% of dietary cholesterol typically undergoes intestinal absorption, the absorption of phytosterols is less than 5%, which explains why the levels of phytosterols found in plant-eating fish and animals are naturally low.
Several different compounds found in food and in the body are classified as lipids. These include triglycerides, cholesterol and phospholipids. Because of certain chemical properties, fat cannot be dissolved in a watery medium unless it undergoes a dispersion process called emulsification, which allows it to remain in suspension as micro-droplets. Chylomicrons are micro-droplets that consist of a mixture of triglycerides (85-92%), phospholipids (6-12%), cholesterol (1-3%) and proteins (1-2%). Their function is to enable the transport of dietary and biliary lipids via a watery medium through the intestinal wall. After absorption and as a component of lymph, chylomicrons are transported via the lymphatic system and deposited into the blood stream. There are two dominant sources of cholesterol present in the upper intestine. These are dietary, obtained from food, and biliary, a source derived from cholesterol which has previously been disposed of by the body as a part of bile through the liver. This form of cholesterol is in a highly absorbable format and is subsequently readily reabsorbed. Typically, about 50% of previously excreted cholesterol is naturally recycled via this pathway.
Due to the structural similarity to cholesterol, phytosterols compete with cholesterol for assimilation into chylomicrons. By helping to block cholesterol absorption, phytosterols help reduce cholesterol blood levels. Both biliary and dietary sources of cholesterol are affected by this mechanism. By blocking biliary cholesterol, phytosterols offer an opportunity to break the continual cholesterol reabsorption cycle. Several human studies (n =16) published prior to the year 2000 have evaluated the effects of phytosterols supplementation under controlled conditions. Collectively, it was found that phytosterols supplementation in various formats including foods, beverages and supplements, was accompanied by an average 10% reduction in total cholesterol and a 13% reduction in LDL cholesterol levels (number of subjects = 590). Moghadasian (1999). Later studies (n =17) demonstrated similar cholesterol and LDL lowering effects (number of subjects = 994). One study quantified the role that phytosterols play regarding the inhibition of cholesterol absorption by measuring the uptake of radioactively marked cholesterol isotopes in human volunteers over a ten-day period. This study determined that the presence of phytosterols reduced tracer marked cholesterol absorption on average by 42%. Ostlund (2003). Two studies evaluating the long-term effects and safety profiles of phytosterols concluded that the cholesterol-lowering benefits were sustained over the long term. Miettinen (1995) Hendriks (2003). Pharmacologically, phytosterols
2) Apple polyphenols
Apples contain several biologically active polyphenols that include the flavonoids and phenolic acids. Observational studies have indicated that the regular intake of apples and apple polyphenols demonstrate a significant potential to modulate several disease processes involved in the development of various degenerative disease states associated with premature death. Boyer J (2004) Hyson DA (2011). In a recent overview published in the British Medical Journal (BMJ), researchers concluded that the positive health benefits associated with the intake of one apple a day were statistically equivalent to the estimated annual reduction in death from cardiovascular events achieved by the statins, a class of pharmaceutical drugs that
Research has indicated that various biological targets and molecular pathways are involved. One of the many purported health benefits that apple and apple polyphenols display is the ability to help lower blood cholesterol levels. In contrast to phytosterols that directly reduce blood cholesterol levels by blocking cholesterol absorption, apple polyphenols indirectly reduce blood cholesterol levels through a different mechanism that involves the absorption of saturated fat. Besides cholesterol, it is well known that other dietary fats also play a dominant role in determining
Large fatty chains cannot be absorbed into the bloodstream until they are reduced in size. This happens naturally through the action of enzymes during digestion, a process that leads to the separation of chemical bonds that join individual fatty acids. In the human body, this process is catalysed by several digestive enzymes called lipases. Fat digestion, or lipolysis, starts in the stomach and continues in the duodenum by means of the combined action of various lipases. The rate at which lipolysis takes place and the consequent supply of free fatty acid to the body can be affected by many factors. These include lipase levels and activity, as well as the presence of lipase inhibitors, agents that reduce the biological activity of lipase.
In the continual search for novel anti-obesity agents, numerous plant-derived phytochemicals have been screened for lipase inhibitory potential. One study examined 132 extracts derived from 106 plant species, used either as food or for traditional medicinal purposes. Tucci (2010). Of these, 26 test extracts inhibited lipase activity by at least 40%. By comparison, extracts from apples demonstrated more than 70% lipase inhibition, a result equalled by only 9 other test extracts. On a cellular level, a study determined that apple polyphenol extracts decreased cholesterol synthesis and lipoprotein secretion in human enterocytes in a
3) Barberry root extract
TrimoStat is a proprietary formulation prepared from barberry root extract. Its main constituent is berberine [C20H18NO4]+, a phytochemical compound belonging to the isoquinoline group of alkaloids which is naturally found in the roots, stems and bark of plants such as Coptis
After absorption and upon entering the bloodstream, chylomicrons containing large quantities of triglyceride and cholesterol are reduced in size into an assortment of lipoproteins through a range of consecutive steps. These are distinguished by their size, density and the proteins that they are composed of. Within its core,
The LDL-receptor (LDL-R) is an integral component of cholesterol homeostasis and the regulation of blood cholesterol and LDL levels. Various factors determine the rate of LDL cholesterol transport between the liver and the peripheral tissues. One of these factors is the number of LDL-receptor sites available on cell surfaces. When LDL-R numbers are inappropriately diminished as a result of genetic defects or in response to regulatory signals, this protective mechanism is lost, cholesterol builds up and atherosclerosis ensues. As in all cells and all receptor sites, the number of surface receptors available is a dynamic process which can be internally adjusted via a regulatory feedback mechanism. During down-regulation, a cell decreases the number of available receptor sites, whilst with
In search of novel agents to up-regulate LDL-R on liver cells through LDL-R expression, various phytochemical compounds used in traditional Chinese medicine were screened. Kong W (2004). Among 700 plant test samples, berberine demonstrated significant activity for increasing LDL-R through expression on human liver cell lines (HepG2), scoring the highest value of all test compounds. Various subsequent studies have repeated these findings, thereby confirming this observation. Adibi P (2005), Brusq JM (2005). Other in vivo studies have examined the molecular pathways involved in LDL-R up-regulation at
4) Coenzyme Q10
Coenzyme Q10 (CoQ10) is a fat-soluble